manufactory Oxytocin Acetate promotion on hot sale CAS NO.50-56-6

SECTION 2: Hazards identification

2:1 Classfication of the substance or mixture

Classification according to Regulation (EC) No 1272/2008

GHS06 skull and crossbones

Acute Tox. 2 H300 Fatal if swallowed.

GHSO8 health hazard

Repr2____ H361 Suspected of damaging frtilty or the unborn child.

Classification according to Directive 67/548/EEC or Directive 1999/45/EC

T+; Very toxic

R28:

Very toxic if swallowed.

Xn; Harmful

R62-63:

Possible risk of impaired frilit! Possible risk of harm to the unborm child.

Information concerning particular hazard

for human 

Not applicable

Other hazards that do not result in

classification

No information known-

2.2 Label elements

Labillng according to Regulation (EC) No

The substance i

; cassified and lbelld according to the CLP regulation.

Hazard pictograms

GHS06. GHS08

Sianal Word

Hazard statements

H308 Fatal if swallowed.

H361 Suspected of damaging fertility or the unbom child.

Precautionary statements

P301+P310 F SWALLOWED: Immedately call a POISON CENTER or doctorphysician.

Specifict

eatment (see onthis label)

P308+P313

P exposed

concerned: Get medical advice/attention.

B485

Dispose of contents/container in accordance with local/regional/nationl/intemational regulations.

Store locked up.

2.3 Other hazards

Results of PBT and vPvB assessment

Not applicable.

VPVB:

SECTION 3: Composition/information on ingredients

3.1 Substances

CAS# Designation:

50-56-6 Oxytocin

Identification number(s):

EC number:

200-048-4

SECTION 4: First aid measures

4.1 Description of first alid measures

General Intormatlon

incaseofirregiar Breathing a respratiry arest provide arificial respiratin,

After inhalation

Supply fresh air. If required, provide artificial respiration.

Keep patient warm. Consult doctor if symptoms

Seek immediate medical advice.

After skin contact

Instanty wash with water and soap and rinse thoroughly.

Seek imimediate medical advice.

After eye contact

Rinse opened eye for several minutes under running water. Then consult doctor.

After swallowing

Do not induce vomiting; instantly call for medical help.

4.2 Most important symptoms and effects,

both acute and delayed

No further relevant information available.

4.3 Indication of any immedlate medical

attention and special treatment needed

No further relevant information avalilable.

 

Oxytocin Usage And Synthesis

Indications and Usage Oxytocin (OT) is a type of uterine contraction drug and can be derived from the animal posterior pituitary or chemically synthesized.

Oxytocin is a uterine contraction drug that is mostly used in late pregnancy induction and stagnant birth due to weak uterine contractions. Suitable for inducing labor and alleviating pain. Commonly used with ergot preparations to be used in inducing labor, expediting labor, and in uterine bleeding due to weak uterine contractions following birth or still birth. Nose drops can be used to promote lactation.

Mechanisms of Action Oxytocin does not contain vasopressin and has no pressure-boosting effects. It can be absorbed through oral mucosa, selectively excite smooth uterine muscle, and intensify its contractions. The uterus is most sensitive to oxytocin when in labor (due to increased estrogen secretion), and an immature uterus will not respond to this drug. During early or mid-term pregnancy, the uterus has a relatively low reactivity to oxytocin, which gradually increases during late-stage pregnancy and peaks during labor. Small doses can strengthen the rhythmic contractions of smooth uterine muscles, increase their contractibility, increase their contraction speed, ensure similar contraction characteristics to that of a natural birth, and maintain polarity and symmetry. Thus, it is used clinically to expedite and induce labor. Large doses cause tonic contractions in the uterine muscles, so it is used clinically to burst blood vessels between muscle fibers, prevent postpartum hemorrhage, and ensuring postpartum recovery. It can also promote lactation by causing the breast ducts to contract and expel milk from the breasts, but it cannot increase the lactation amount.

Pharmacokinetics Ineffective when taken orally, as it can be damaged by digestive fluids, although it can be absorbed through oral mucosa. 1-3 minutes of venous infusion 0.01 IU can induce physiological uterine contractions (Rhythmic, polar, symmetrical) with a short time span, as its half-life is only 2.5-3 minutes. Large doses cause tonic uterine contractions.

Adverse reactions Oxytocin derived from cow or pig’s pituitary occasionally causes allergic reactions, and infusing too quickly may lead to mild vasodilation and hypotension. Patients who suffer from abruptio placentae, heart disease, or enlarged uterus, are over 35 years old, have a history of cesarean section or uterine muscle tumor removal, or are experiencing a breech birth should use with caution. Using oxytocin while experiencing a sacral block may lead to severe hypertension and even cerebrovascular rupturing. Cannot be injected in the same solution with norepinephrine. Incompatible with hydrolyzed proteins.

Contradictions Do not use during birth if there are obvious signs of an unsymmetrical head, incorrect fetal position, exposed umbilical cord, prolapse, complete placenta previa, narrow pelvis, or overly intense uterine contractions. Not to be used by patients with overly narrow pelvises, histories of uterine surgery (including C-sections), excessive pains, blocked birth canals, abruptio placentae, or pregnancy poisoning.